Remedies for ischemic disease

Patent Number: 7,473,425

This patent essentially covers the combination of G-CSF with HGF, together with a clinically used pharmacotherapy, for the treatment of ischemic disease of a limb.  Classically it has been difficult to induce therapeutically significant angiogenesis using single angiogenic compounds.  Some companies are using cells as secretors of angiogenic agents since cells produce the "symphony of growth factors" which are difficult to reproduce by adding single cytokines.  In this patent, the inventors demonstrate a synergy between G-CSF and HGF, and cover the use of this synergy together with conventional agents such as PGE-1. 

The patent's dependent claims cover dosages of G-CSF as well as specific drugs in clinical use such as antiplatelet agents,  microcirculation improvers, anticoagulants and/or an antilipemic agents.

View this patent on the USPTO website.