Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans

Patent Number: 6864235

The ability of cells to respond to danger signals is associated with how the host will respond to injury in general. This patent is based around observations that cellular injury is associated with upregulation of certain danger signal associated molecules, which the inventors call "transition molecules". This is most likely why the name of one of the companies that the inventors established, which uses this patent is called "Transition Therapeutics".

Essentially, the transition molecules, such as hyaluronic acid, turn on various biological responses in the host. Such responses can be pathological in many circumstances.

In this patent the inhibition of interaction between transition molecules and the molecules of the host is used for therapeutic benefit. For example, in this patent inhibition of hyaluronic acid interaction with RHAMM using various compositions of matter is claimed.

View this patent on the USPTO website.