Mesenchymal stem cells as immunosuppressants
Patent Number: 6797269
Date of First Priority Issue: Friday April 3rd, 1998
Date Issued: Tuesday September 28th, 2004
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Inventors: Mosca, Joseph D. (Ellicott City, MD); McIntosh, Kevin R. (Ellicott City, MD)
From Class: Use
Comments: No comments
This patent covers mesenchymal stem cells that are treated with interferon gamma for suppression of an immune response. Mesenchymal stem cells are naturally immunosuppressive...it may be that the interferon gamma treatment is activating the expression of the immune suppressive enzyme 2,3-indolamine-dehydrogenase (IDO), which selectively depletes tryptophan, thus stopping T cell activation.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
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