Materials and methods relating to the transfer of nucleic acid into quiescent cells
Patent Number: 6723561
Date of First Priority Issue: Thursday September 28th, 1995
Date Issued: Tuesday April 20th, 2004
Assignee: Mayo Foundation for Medical Education and Research (Rochester, MN)
Inventors: Russell, Stephen James (Cambridge, GB); Fielding, Adele Kay (Cambridge, GB); Casimir, Colin Maurice (London, GB)
From Class: Use
Comments: No comments
The early hematopoietic stem cells are usually non-proliferating, additionally, intermediately developed hematopoietic stem cells treated with stem cell inhibitors such as TGF-beta, also do not proliferate. This causes a problem for gene therapy since most gene therapy vectors require the cells to be proliferating for appropriate transfection. This patent teaches methods of transfecting cells, especially primitive hematopoietic cells with foreign genes, even if the cells are in a quiescent or G0 state.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
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