Patents (1436 Stem Cell Patents)

Treatment of liver disease and injury with CXC chemokines

Patent Number: 6719969

Date of First Priority Issue: Monday August 9th, 1999
Date Issued: Tuesday April 13th, 2004
Assignee: The Regents of The University of Michigan (Ann Arbor, MI); University Court of The University of Edinburgh (GB)
Inventors: Hogaboam, Cory M. (Ann Arbor, MI); Bone-Larson, Cynthia L. (Petersburg, MI); Simpson, Kenneth J. (Edinburgh, GB); Lukacs, Nicholas W. (Brighton, MI); Kunkel, Steven L. (Ann Arbor, MI); Colletti, Lisa M. (Webberville, MI); Strieter, Robert M. (Sherman Oaks

From Class: Use

This patent teaches that CXC chemokines are potent stimulators of hepatic stem cells and hepatic regeneration. Chemokines covered include MIP-2, ENA-78 and IL-8.

View this patent on the USPTO website.

Added to StemCellPatents.com on Monday October 16th, 2006

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2 Comments | Add Comment

joseph said...

Created 2006-12-09 12:34:19 EST

Do the CXC chemokines actually call in bone marrow cells to fix up liver, or do they work endogenously on hepatocytes?

I do not understand whether the oval cell itself is a stem cell, or whether there are other stem cells that give rise to oval cells in the liver?

Also, is it true that Oval cells have CD34 on them, just like bone marrow stem cells?

- 1 -

Carmen said...

Created 2006-12-09 12:36:49 EST

The adult liver has 2 types of stem cells, these are oval cells and small hepatocytes (some call them “small hepatic like progenitor cells”).

Oval cells are called bipotential hepatic progenitors (can become hepatocytes or biliary epithelial cells), they are induced by hepatic damage during conditions which do not allow mitosis of mature hepatocytes. Some say that oval cells can differentiate into small hepatic like progenitor cells.

Oval cells express stem cell antigen, c-kit, flt-3, CD34, and Thy-1 (CD90).

- 2 -

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