Hematopoietic cell composition for use in transplantation

Patent Number: 7101708

This patent is useful for parties looking to increase bone marrow stem cell homing to areas of need. In normal bone marrow transplants, stem cells from the donor are introduced intravenously and find their way to the bone marrow by virtue of bone marrow-secreted stromal derived factor-1 (SDF-1). It was more recently discovered that following tissue injury (for example stroke and myocardial infarction), the injured tissue secretes SDF-1 which causes mobilization of stem cells to the site of injury. The patent has 2 independent claimes. The first covers methods of preparing cells expressing high concentration of the receptor for SDF-1 (CXCR-4) through culture with various agents, whereas the second independent claim covers methods of expanding cells with high level of CXCR-4 expression. The patent seems to be described in a publication (Kollet O et al. Blood. 2002 Oct 15;100(8):2778-86). It appears that this patent is available for licensing (Sept 26, 2006) from Yeda Research and Development Co. Ltd. P.O. Box 95, Rehovot,76100, Israel Tel: +972-8-947-0617 Fax: +972-8-947-0739

View this patent on the USPTO website.