Hematopoietic stimulation

Patent Number: 7067489

The invention is useful for stimulating hematopoiesis, preventing low levels of hematopoietic cells and producing increased numbers of hematopoietic and mature blood cells which can be used both in vivo and in vitro. It appears that CD26 is a peptidase that cleaves certain proteins, including hematopoietic growth factors. Additionally, CD26 cleaves SDF-1 the chemotactic signal that calls in stem cells to the bone marrow Specifically, the inventors have found that a composition that inhibits CD26 activity can also stimulate hematopoiesis. The composition is called "PT-100", which is a dipeptide consisting of valine-prolineboronic acid. The patent has 1 independent claim, the claim covering method of increasing growth factor production by stromal cells in vivo. The inventors have published what appears similar data to the patent ( Jones B et al. Hematopoietic stimulation by a dipeptidyl peptidase inhibitor reveals a novel regulatory mechanism and therapeutic treatment for blood cell deficiencies. Blood. 2003 Sep 1;102(5):1641-8. bjones@pther.com).

View this patent on the USPTO website.