Methods and devices for the long-term culture of hematopoietic progenitor cells

Patent Number: 7067316

This patent is useful for the long term, in vitroculture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors. It appears that the inventors developed a system that replicates the bone marrow structure but does not require addition of cytokines or other growth factors, or serum. The invention has 2 independent claims. The first covers a porous, solid matrix having interconnected pores of a pore size sufficient to permit said cells to grow. The first independent claim covers changing media at least 1 time per week for as many weeks as desired, wherease the second on covers growth cells for 1 week without media change.

View this patent on the USPTO website.