Anti-transforming growth factor Beta (TGF-.beta.) treated stem cell composition and method
Patent Number: 6627191
Date of First Priority Issue: Monday January 25th, 1999
Date Issued: Tuesday September 30th, 2003
Assignee: Seattle Biomedical Research Institute (Seattle, WA)
Inventors: Bartelmez, Stephen H. (Seattle, WA); Sitnicka, Ewa (Lund, SE); Ruscetti, Frank (New Market, MD)
From Class: Expansion
Comments: No comments
This patent teaches the use of antibodies to TGF beta in order to stimulate hematopoietic stem cell renewal. Hematopoietic stem cells generation secrete autocrine TGF beta which inhibits their proliferation. This patent inhibits the inhibitor thus attaining stem cell expansion.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
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