Neural transplantation using pluripotent neuroepithelial cells

Patent Number: 7048921

This patent covers ways of treating neurological deficiencies or damage through transplantation of specific types of stem cells, or progenitor cells. Specifically, the patent has 3 independent claims. The first independent claim covers the intracerebrally transplantation of pluripotent, nestin-positive, neuroepithelial cells that have been conditionally immortalized through genetic manipulation. The second independent claim covers essentially similar subject matter, with the exception that conditional immortalization is performed by transfection with the SV40 large T antigen. The third independent claim covers brain damage in the hippocampus with an approach essentially similar to independent claim 2.

View this patent on the USPTO website.