Method of decreasing radiation of radio-mimetic chemotherapy for hematopoietic pluripotent cell engraftment

Patent Number: 6103694

This patent teaches how to perform hematopoietic stem cell transplants without myeloablating the recipient. This patent provides specific doses of radiation that can mimic the effects of chemotherapy.

This patent may be useful for other types of stem cell therapy in order to temporarily suppress the recipient immune system so as to allow the transplanted cells to engraft, establish themselves, and hopefully induce tolerance so that when the immune system reconstitutes they do not get rejected.

These radiation doses, if truly effective as immune suppressants, may also be used for treatment of diabetes by irradiating the pancreas in such a manner as to only kill infiltrating lymphocytes.

View this patent on the USPTO website.