This patent teaches how to grow bone marrow stromal cells in vitro. Several types of culture conditions for growing stromal cells are given. For example, the stromal cells may be expanded by treatment with FGF-1 on gelatin-coated plates. If FGF-1 can stimulate stromal cells in vitro, one wonders whether it also has similar in vivo abilities. The reason this is important is that there are currently ongoing clinical trials that used FGF-1 for induction of angiogenesis both for the heart as well as limb ischemia.
View this patent on the USPTO website.
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