Lineage-directed induction of human mesenchymal stem cell differentiation
Patent Number: 5942225
Date of First Priority Issue: Tuesday January 24th, 1995
Date Issued: Tuesday August 24th, 1999
Assignee: Case Western Reserve University (Cleveland, OH); Osiris Therapeutics, Inc. (Baltimore, MD)
Inventors: Bruder, Scott P. (Owings Mills, MD); Caplan, Arnold I. (Cleveland Heights, OH); Haynesworth, Stephen E. (Cleveland Heights, OH)
From Class: Differentiation
Comments: No comments
Disclosed are tissue culture conditions that can direct the differentiation of mesenchymal stem cells into the following cell lineages: osteogenic, chondrogenic, tendonogenic, ligamentogenic, myogenic, marrow stromagenic, adipogenic and dermogenic.
This patent is useful for the generation of artificial tissue. Although the mesenchymal stem cells themselves are poorly immunogenic, the tissue deriving from them should be immunogenic. This is an issue that should be considered.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
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