Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system
Patent Number: 7022321
Date of First Priority Issue: Saturday October 4th, 1997
Date Issued: Tuesday April 4th, 2006
Assignee: Unknown Assignee(s)
Inventors: Eglitis, Martin A. (Indianapolis, IN); Mezey, Eva (Rockville, MD); Mouradian, Mary Maral (Bethesda, MD)
From Class: Use
Comments: No comments
This patent capitalizes on the ability of bone marrow cells to migrate into the brain and cause repairative function. The patent uses bone marrow cells as a "vector" in order to deliver glial cell line-derived neurotrophic factor (GDNF) to the area of need. The patent has 2 independent claims both covering "A method of treating Parkinson's disease, ". The first covers administration of bone marrow cells transfected with GDNF, whereas the second covers specific cytokines to grow the bone marrow cells in, and a specific vector for transfecting the bone marrow cells with the GDNF.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
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