Stimulation, production, culturing and transplantation of stem cells by fibroblast growth factors
Patent Number: 5817773
Date of First Priority Issue: Friday June 8th, 1990
Date Issued: Tuesday October 6th, 1998
Assignee: New York University (New York, NY); Sloan-Kettering Institute for Cancer Research (New York, NY)
Inventors: Wilson, Elaine Lynette (New York, NY); Gabrilove, Janice (New York, NY)
From Class: Expansion
Comments: No comments
This patent teaches that members of the FGF family are useful for expansion of hematopoietic stem cells. This is interesting since FGF-2 was actually used in the clinic for treatment of stroke. Although results were impressive in small subsets of patients, the adverse effects of systemic administration of this protein stopped its clinical development. According to this patent the systemic administration of FGF-2 should have actually stimulated hematopoiesis, I wonder if leukocytosis was seen in patients recieving systemic FGF-2???
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
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