Use of interferon .gamma. for the inhibition of proliferation and differentiation of primitive hematopoietic progenitor cells
Patent Number: 5807744
Date of First Priority Issue: Saturday August 13th, 1994
Date Issued: Tuesday September 15th, 1998
Assignee: Boehringer Mannheim GmbH (Mannheim, DE)
Inventors: Berneman, Zwi (Antwerp, BE); Van Bockstaele, Dirk (Edegem, BE); Snoeck, Hans-Willem (Antwerp, BE)
From Class: Expansion
Comments: No comments
This patent teaches that the Th1 cytokine interferon gamma inhibits proliferation of hematopoietic stem cells. In one use, this cytokine may be administered to cultures of bone marrow harvested from cancer patients for autologous transplant, the administration of interferon gamma would protect the stem cells from chemotherapy which would kill residual cancer cells. Additionally, the interferon gamma may activate NK cells as well to directly kill tumor cells.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
Social & Bookmarking:
Add Comment
You must be signed-in to add your comments.
Sign-in now or Join the StemCellPatents.com Community for free.