Hematopoietic stem cell specific gene expression
Patent Number: 5556954
Date of First Priority Issue: Thursday February 13th, 1992
Date Issued: Tuesday September 17th, 1996
Assignee: Beth Israel Hospital Boston Association (Boston, MA)
Inventors: Burn, Timothy C. (Bedford, MA); Satterthwaite, Anne B. (Brighton, MA); Tenen, Daniel G. (Boston, MA)
From Class: Use
Comments: No comments
This patent covers the promoter for CD34. CD34 is a classical marker of stem cells, not only of the hematopoietic type but also of the hepatic type. CD34 is highly glycosylated and acts as an adhesion molecule. Mice that are knocked out for CD34 still have hematopoiesis, however the stem cells to not migrate properly.
The current patent can be used for many things, including placing different markers in front of CD34 promoter so to make it easier to purify stem cells.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
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