Method for protecting bone marrow against chemotherapeutic drugs using transforming growth factor beta 1
Patent Number: 5278145
Date of First Priority Issue: Thursday June 29th, 1989
Date Issued: Tuesday January 11th, 1994
Assignee: The United States of America as represented by the Department of Health (Washington, DC)
Inventors: Keller, Jonathan R. (Frederick, MD); Ruscetti, Francis W. (Rockville, MD); Wiltrout, Robert (Frederick, MD)
From Class: Expansion
Comments: No comments
TGF-beta is an inhibitor of hematopoietic stem cell proliferation. It is known that autologous TGF-b is involved in keeping stem cells in a quiescent G0 state. This patent teaches the systemic administration of TGF-b before administration of a chemotherapeutic drug so as to protect the stem cells from damage.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
Social & Bookmarking:
Add Comment
You must be signed-in to add your comments.
Sign-in now or Join the StemCellPatents.com Community for free.