Category: Differentiation (37)
Blood to Muscle: Hematopoietic transdifferentiation to muscle
Providence, RI - Numerous scientists, such as Irv Weissman, continually make the point that a hematopoietic stem cell will only differentiate into a cell of the hematopoietic lineage. Such statements appear, at face value, to contradict the numerous clinical trials ongoing using bone marrow stem cells for the treatment of conditions ranging from heart failure, to liver failure, to...
Prolactin protects white matter
Calgary, Canada - A recent paper (Gregg et al. White matter plasticity and enhanced remyelination in the maternal CNS.J Neurosci. 2007 Feb 21;27(8):1812-23) describes an increased generation of myelin-forming oligodendrocytes and increased number of myelinated axons in mice that are pregnant as compared to female controls. The study also demonstrated...
Mesenchymal Stem Cells To Islets
Tel Aviv, Israel -
Mesenchymal stem cells are very promising as a vehicle for transfection with various genes. This is because mesenchymal stem cells can easily be expanded, can be used allogeneically, and have a rather broad proliferative potential.
In terms of using mesenchymal stem cells for treatment of diabetes, it has been reported that
Forcing Differentiation
Durham, NC - Classically hematopoietic stem cells were known to differentiate into myeloid (monocyte and granulocyte) and lymphoid (T cell, B cell, NK cell) lineages. More recent studies have demonstrated differentiation into cardiomyocytes, neurons, and other tissue cells. The signals associated with hematopoietic stem cell differentiation into myeloid and lymphoid cells are currently...
Cord Blood To Skin
Nanchang, China - The use of stem cells for burn injury is attractive not only for repairing injured tissue directly and through trophic factor secretion, but also by their potential to inhibit inflammatory responses. In a recent paper (Dai et al. Skin epithelial cells in mice from umbilical cord blood mesenchymal stem cells. Burns. 2007 Apr 26) cord blood mesenchymal stem cells were...
ES to Islet
Seoul, Korea - A recent study (Shim et al. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia. 2007 Apr 23) reported generation of functional islet-like cells from human ES cells through the following steps: 1. ES cells placed in suspension culture to promote embryoid body formation 2. Culture in serum 3. Add activin 4. Add retinoic...
Sweet BM: Glucose changing BM to pancreatic like cells
[Watch the Video] US Patent 7,169,608
Patent on Making Pancreatic Tissue from HSC and MSC
Making ES cells into Beta Cells that Work !
Beijing, China - Treatment of diabetes by stem cell derived beta calls is an attractive prospect. Jiang et al (In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res. 2007 Apr 10) recently reported a serum free method of inducing ES cells to differentiate into cells capable of producing insulin in vitro and in vivo. The investigators treated...
ES to endothelium by VEGF tx
Singapore - The ability to generate new endothelial cells would allow for treatment of a wide variety of diseases in which ischemia acts as a culprit. Use of stem cells, as well a growth factors for stimulation of new blood vessel production, a process called angiogenesis has been a topic of intense research and clinical investigation. In a recent paper (Rufaihah et al. Directing...