Category: Differentiation (37)
Turning it up a Notch
Notch is a very interesting molecule. It acts as a receptor (for ligands such as Serrate), as well as a transcription factor when activated. The role of Notch in assigning tissue fate is established across the animal kingdom.
A patent at StemCellPatents.com # 7,138,276, entitled Differentiation-suppressive polypeptide serrate-2... Xian, China –
Fat derived stem cells offer numerous therapeutic possibilities since they are available large amounts from autologous starting material.
In a recent paper (Wei et al. Regulation of adipose-derived adult stem cells differentiating into chondrocytes with the use of rhBMP-2. Cytotherapy. 2006;8(6):570-9.) it was demonstrated that culturing of fat derived stem cells with the... Watertown, MA
Girgenrath M et al published in today's online version of EMBO a paper entitled TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration which demonstrates the ability of inflammatory stimuli to induce mesenchymal stem cell proliferation.
The... Sydney Australia -
In a study published in today's issue of Stem Cells, Australian scientists reported a unique methodology for coaxing olfactory adult stem cells to acquire the phenotype of cochlear hair cells. This finding is important because deafness results from loss of cochlear hair cells and the ability to generate these cells in vitro would conceptually open the door for cell... Seoul South Korea -
Jeon et al published today in the online version of the Journal of Cell Sciences that exposure of mesenchymal stem cells to the lipid sphingosylphosphorylcholine (SPC) induces differentiation into smooth muscle cells in a paper entitled
"Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a 
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BMP-2 Induces Fat Stem Cells to Become Cartilage
Inflammation TWEAKs Stem Cell Expansion
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Nose to Hair: Differentiation of Olfactory Stem Cells
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Lipid Stimulation of Mesenchymal Differentiation
Electrical signals inducing stem cell differentation
Saitama Japan- In today's issue of the journal Stem Cells, Yamada et al reported that electrical stimulation of embryonic stem cells resulted in induction of differentiation into the neural lineage. In a paper entitled "Electrical stimulation modulates fate determination of differentiating embryonic stem cells", the authors demonstrated that embryonic stem cells differentiated by electrical...
Synchronization of Differentiation is Key
LONDON UK Researchers in the UK have published in today's online version of the journal Nature (Maclaren et al. Retinal repair by transplantation of photoreceptor precursors, Nature. 2006 Nov 8.) an important finding in regards to stem cell therapy of photoreceptor loss It was known in the art that transplantation of a wide variety of stem...