Category: Hepatic (14)
Bone Marrow Changing to Liver
New Delhi, India - There are numerous reports in the literature of bone marrow cells "transdifferentiating" into hepatocytes, or alternatively, bone marrow cells having hepatic precursors that can differentiate into hepatocytes. The possibility of this occuring is substantiated by studies in sex mismatch clinical bone marrow transplant recipients in which liver biopsies from the recipient...
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Mesenchymal stem cells to liver
Hangzhou, China - The ability of bone marrow derived mesenchymal cells to differentiate into various lineages is well-known. A recent paper (Chen et al. Hepatocytes induced by conditioned culture medium of hepatocytes. J Cell Biochem. 2007 Mar 5;) describes a novel protocol for inducing differentiation of mesenchymal stem cells into hepatocytes. Essentially, mesenchymal stem cells were...
Liver regeneration by inhibiting the inhibitor
Kayseri, Turkey - Readers of StemCellPatents.com will be familiar with patents describing the inhibition of TGF-beta as a means of stimulating stem cell proliferation. Essentially, it is known in the hematopoietic system at least, that autocrine production of TGF-beta by stem...
ES cells to Hepatocytes
Bethesda MD - Readers of StemCellPatents.com are familiar with the patent of Loren Field which teaches that tissue-specific promoters can drive expression of markers from embryonic stem cell cultures so as to be able to selectively "fish out" stem cells that are starting to commit to a specific lineage. In a recent paper...