Category: Cardiac (32)
Stem cells improve post-infarct heart function
Chicago, IL -
The use of bone marrow stem cells post infarct has been reported to induce improvements in various cardiac parameters post-infarct. In fact, even administration of stem cells in patients after chronic cardiac deterioration has been reported to have beneficial effects, although these are much more...
1 Comment
Preventing Diabetes Associated Cardiac Dysfunction by MSC
Cairo, Egypt -
Bone marrow stem cell therapy is being clinically used by various institutions for treatment of non-hematopoietic diseases. For example, it has been previously reported in clinical trials that administration of bone marrow cells prevents pathological cardiac remodeling post-infarct. ...
2 Comments
Neostem's VSEL Cells Have Biological Significance
Katowice, Poland -
Biological significance is a very important factor to look at when evaluating various stem cell technologies or types of stem cells. While companies usually like to believe that their stem cells are "the best", it is often important to ask the question whether the stem cells play a natural role in the body, and if therapeutically that role can be...
Cardiac Stem Cell Therapy in 2 Year Old
Giessen, Germany -
Adult stem cell therapy has previously been used for heart failure, primarily in acute post-infarct situations. In a very interesting paper (Rupp et al. Intracoronary administration of autologous bone marrow-derived progenitor cells in a critically ill two-yr-old child with dilated cardiomyopathy. Pediatr Transplant 2008 Nov 26) autologous bone...
Potentiating Mesenchymal Stem Cells for Cardiac Regeneration
Cincinnati, Ohio -
Mesenchymal stem cells are attractive for therapeutics development because they can theoretically be used as a "one size fits all". Additionally, their ability to home to area of tissue injury, in part by CXCR4 expression allows for...
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Sensitizing CML Precursors to GVL
Bethesda, Maryland -
Chronic myeloid leukemia (CML) is a cancer of the myeloid committed stem cell, which is caused primarily by the oncogenic chimeric protein BCR-ABL. Immune responses are known to control progression of CML. For example, patients with CML taking interferon that have higher NK cell activity live longer. There are many...
Interferon gamma as a "danger signal"
Boston, MA -
Although stem cell therapy has demonstrated some benefit in a variety of cardiac conditions, heart transplantation is still the only option for many patients with end-stage heart failure. The problem with heart transplantation is that firstly there are not enough donors, and secondly, the patients have to take immune suppressive...
2 Comments
Stem Cell Cytokines Preventing Ischemia Reperfusion
Osaka, Japan -
Granulocyte colony stimulating factor (G-CSF) is one of the largest selling products of the biotechnology industry. Approved uses of this recombinant cytokine include stimulation of neutrophil production after chemotherapy or bone marrow transplantation. Another use is in mobilizing the hematopoietic stem cells to... Indianapolis, Indiana -
It is safe to say that the actual implimentation of stem cell therapy clinically is actually more being performed for purposes of immune modulation than actually growing of new tissues. For example, mesenchymal stem cells are most advanced clinically in the USA by the company Osiris, which are... Warsaw, Poland -
The immune system is activated in response to Danger signals, which evoke various innate molecular pathways that culminate with inflammatory cytokine production and eventual activation of the adaptive immune system. Stem cells circulating in lymphatics have been implicated in recognizing classical danger...
IL-18 in the Heart
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Importance of the Injury Signal
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