Category: 3 Dimensional Structures (6)
Embryonic stem cells into urinary epithelium
Asahi, Japan - Generation of three dimensional structures that can be implanted into patients is one of the exciting prospects offered by stem cell technologies. For example, three dimensional structures such as heart valves and "uteri"https://www.stemcellpatents.com/patents-show-51 have already been engineered in vitro. One...
Bone Marrow-Like Bioreactor
Detroit, Michigan - The ex vivo expansion of hematopoietic stem cells in large numbers would allow for numerous autologous transplant approaches to become a clinical reality. For example, one could hypothetically expand and keep frozen their own stem cells for when they need them later in life. Unfortunately, many attempts at expanding CD34 hematopoietic stem...
Activators of Endogenous Stem Cells for Diabetes Therapy
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Discussed is the use of gastrin and EGF to stimulate endogenous stem cells for regeneration of islets. The paper is striking since not only is diabetes stopped and active islet regeneration occurred...but suppressor cells seemed to be generated that actively blocked diabetogenic activity of splenocytes. The 
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Nano meets stem cells
Durham, NC – As stem cell therapeutics progress towards becoming a clinical reality, it is becoming more and more apparent that not only is it important to administer the proper type of stem cells, but also to ensure that a proper environment surrounds them, so that they may differentiate into the needed tissue. In a recent paper (Yim et al. Synthetic nanostructures inducing...
EGF-Tethered Matrices
Boston, MA - The utilization of mesenchymal stem cells for healing of tissue defects, or for example, bone fractures, best occurs when the stem cells are implanted using a supportive matrix. Although a wide variety of such matrices are known to exist, one of the major problems is how to have the stem cells not only grow on the matrix, but also exhibit properties similar as if the stem...
Artificial Cartilage Implant
Boston, MA- Artificial joints and components generated in vitro for surgical implantation in patients with injured joints is an area of intense research and commercialization interest. Hydrogels are generally defined as a network of polymer chains that are water-soluble and can be used for implantation of drugs or cells into a desired anatomical area. In a recent paper (Hannouche D...
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