HLG-G made by mesenchymal stem cells

Monday October 15th, 2007 @ 19:46:23 EST

From Category: Use
Comments: No comments

Besancon, France -

The ability of mesenchymal stem cells to inhibit inflammatory immune responses has been established in in vitro models, as well as in clinical trials of inflammatory conditions, such as the trials of Osiris for treatment of GVHD and Crohn's disease.

In a recent paper (Selmani Z et al. HLA-G5 secretion by Human Mesenchymal Stem Cells Is Required to Suppress T-lymphocyte and NK Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells) a novel mechanism by which mesenchymal stem cells inhibit the immune response was described.

The investigators identified that mesenchymal stem cells secrete a soluble isoform of HLA-G called HLA-G5. By addition of blocking antibodies to HLA-G5 the investigators were able to abrogate MSC induction of:

1. Inhibition of allogeneic T cell proliferation
2 Expansion of CD4CD25FOXP3 regulatory T cells

Additionally, they demonstrated that the soluble HLA-G5 was capable of inhibiting natural killer cell production of interferon gamma, as well as cytotoxicity.

This study supports the possibility of using mesenchymal stem cells in the treatment of multiple sclerosis, as presented in the video below.

Click play button.


Social & Bookmarking:Digg 'HLG-G made by mesenchymal stem cells' Add 'HLG-G made by mesenchymal stem cells' to del.icio.us Add 'HLG-G made by mesenchymal stem cells' to Technorati Stumble 'HLG-G made by mesenchymal stem cells' Add 'HLG-G made by mesenchymal stem cells' to Furl Add 'HLG-G made by mesenchymal stem cells' to Reddit Add 'HLG-G made by mesenchymal stem cells' to Blinklist Add 'HLG-G made by mesenchymal stem cells' to Ma.gnolia Share 'HLG-G made by mesenchymal stem cells' on Facebook Add 'HLG-G made by mesenchymal stem cells' to Google Add 'HLG-G made by mesenchymal stem cells' to Yahoo Web 

Add Comment

You must be signed-in to add your comments.

Sign-in now or Join the StemCellPatents.com Community for free.



Home | News | Patents | Products | Jobs | Links | Search | Journal | RSS

About | Advisory Board | Newsletter | Advertise | Contact | Sitemap | Privacy Policy | Terms of Use

Copyright © 2006 - 2024 StemCellPatents.com - All rights reserved. - Toronto Web Design

StemCellPatents.com V2.04

Stouffville Concrete | Tottenham Concrete | Uxbridge Concrete | Gerogetown Concrete | Rockwood Concrete | Kleinburg Concrete | Stouffville Real Estate Agent