Stem Cell Analgesia
Atlanta, Georgia -
There are currently numerous clinics utilizing stem cell therapies for a wide variety of indications ranging from ALS to autism. These stem cells are usually cord blood derived, or autologous bone marrow cells. Although little mechanistic work has been performed, the clinical use of stem cells is associated with patients having favorable subjective responses.
A recent study (Klass et al. Intravenous mononuclear marrow cells reverse neuropathic pain from experimental mononeuropathy.Anesth Analg. 2007 Apr;104(4):944-8) demonstrated analgesic effect of autologous bone marrow mononuclear cells.
Rats underwent sciatic nerve chronic constriction injury and were injected with 10 million bone marrow mononuclear cells intravenously. Pain was determined by hypersensitivity using paw withdrawal latency test and assessed by a blinded observer.
10 days after induction of sciatic nerve injury bone marrow treated rats had longer latency of response to stimuli as compared to controls, thus indicating a less degree of pain.
The authors concluded that "stem or progenitor cell-mediated therapies may be useful for the treatment of pain after nerve injury".
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3 Comments | Add Comment
Tania said...
You know how many people take stem cells ex us? Maybe stem cells would be useful for treatment of neuropathic pain !!
notch1 said...
to james -
"hematopoietic stem cells make a variety of neural mediators such as substance p"
by what way? how HSC can make neuro-mediators?
don't you think that HSC can stimulate resident neuronal cells to make it? For me it's seem like paracrynic regulation.
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james said...
The possibiilty of stem cells having therapeutic effects on the nervous system is interesting. I do think that hematopoietic stem cells make a variety of neural mediators such as substance p.