Class: Mobilization (30)
Mobilization of peripheral blood precursor cells by .beta.(1,3)-glucan
Patent Number: 6117850This patent teaches how to mobilize stem cells through administration of beta glucan and various derivatives of it. The use of other immune stimulants and TLR agonists should be evaluated for mobilization in future.
Stem cell immobilization
Patent Number: 5912177This patent covers methods of "grabbing" stem cells by virtue of a fibrin matrix together with RGD binding motifs. The attachment of stem cells to various structures may be useful as a means of harvesting stem cells.
Increase in hematopoietic progenitor cells in peripheral blood by transforming growth factor .beta.
Patent Number: 5674843This patent teaches that the stem cell inhibitory compound TGF-beta may be administered for the purpose of mobilization.
Release and mobilization of haematopoietic cells
Patent Number: 5925568This patent teaches that the chemokines MIP-1 alpha/LD78 are capable of causing the mobilization of stem cells from the bone marrow. This patent is useful for increasing the number of circulating stem cells from a donor so that peripheral blood may be harvested for stem cells for transplantation. Additionally, mobilization may be performed in a patient with a...
Method of mobilizing hematopoietic stem cells
Patent Number: 6447766Peripheralization of hematopoietic stem cells
Patent Number: 5843438This patent covers the use of anti-VLA-4 and anti-VCAM antibodies for mobilizing stem cells from the bone marrow. Stem cell mobilization is induced by the antibodies blocking the binding of the hematopoietic stem cells to the bone marrow stroma.
Peripheralization of hematopoietic stem cells
Patent Number: 5824304This patent teaches how to treat HIV by removal of mobilized stem cells (stem cell mobilization by anti-VLA4 antibody), administering chemo or radiotherapy, and then subsequently reinfusing the purified stem cells to reconstitute the hematopoietic system.
Peripheralization of hematopoietic stem cells
Patent Number: 5695755This patent covers mobilization of hematopoietic stem cells by administration of antibodies to VCAM or VLA-4.
Methods of blocking the interaction between stromal cells and hemopoietic cells with anti-VCAM-1 antibodies
Patent Number: 7,449,186Mobilization is currently performed using agents such as G-CSF clinically, experimentally agents such as parathyroid hormone are being investigated. The current patent teaches a new way to mobilize through blocking the interaction between hematopoietic stem cells and their stromal microenvironment using antibodies to...
Method for homing hematopoietic stem cells to bone marrow stromal cells
Patent Number: 6258354This patent covers the use of gene transfected stromal cells in order to increase engraftment of a hematopoietic stem cell transplant.