Class: Mobilization (30)
Method for enhancing stem cell trafficking
Patent Number: 6814961This patent teaches the use of a naturopathic remedy for actually mobilizing stem cells into systemic circulation. The naturopathic remedy is blue green algae. This patent may be used for treating anything that benefits from mobilized stem cells ranging from stroke to myocardial infarction.
CXCR4 antagonist treatment of hematopoietic cells
Patent Number: 7,435,718This is a composition of matter patent covering chemical antagonists of the receptor CXCR-4. This receptor binds to stromal derived factor (SDF-1, otherwise known as CXCL12) and maintains the hematopoietic stem cells in the bone marrow. When the receptor is antagonized the hematopoietic stem cells mobilize into circulation. This can be used for...
CaR receptor as a mediator of migratory cell chemotaxis and/or chemokinesis
Patent Number: 7,176,243The area of stem cell mobilization is very exciting not only from the perspective of allowing for efficient harvest of peripheral blood stem cells, but also from the perspective of one day being able to mobilize endogenous stem cells to accelerate healing of various organs. In this patent a novel method of inducing mobilization of stem cells from the bone marrow, as well as inhibiting...
Growth factor therapy mobilization of stem cells into the peripheral blood
Patent Number: 7,288,521This patent covers a new way of mobilizing stem cells. Stem cell mobilization is usually performed on the donor of a hematopoietic graft so that instead of needing to puncture the donor bones to get bone marrow, the stem cells are "forced" into circulation by administration of a growth factor. Conventionally mobilization of stem cells is performed by systemic administration of G-CSF. In...
Purposeful movement of human migratory cells away from an agent source
Patent Number: 7,141,363Chemotactic gradients are critically important in stem cell function. This is demonstrated not only in the fact that the bone marrow constitutively secretes SDF-1 in order to allow systemically infused stem cells to home back to the bone marrow, but also in regenerative medicine where injured tissue releases chemokines to attract endogenous stem cells. The...
Methods for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood in a patient in need of chemotherapy
Patent Number: 6566335This patent teaches ways of mobilizing hematopoietic stem cells by administration of angiotensin I and/or II and/or analogues thereof.
Molecules that home to various selected organs or tissues
Patent Number: 6610651This patent covers peptides that specifically home to the lung. This patent is useful for delivering compounds that activate pulmonary stem cells to the lung. Since injected stem cells generally go to the lung, the administration of stem cell factors targeted to the lung using these peptides in combination with exogenous stem cells may be a new therapeutic approach.
Methods for cell mobilization using in vivo treatment with hyaluronan (HA)
Patent Number: 7,446,100Stem cell mobilization is important commercially/medically from several angles. Firstly, donors of hematopoietic stem cells usually prefer to have their bone marrow resident stem cells "mobilized" so as to enter the blood and be collected from blood as opposed to having holes drilled in their iliac crest. Secondly, for some types of cancer, autologous hematopoietic stem...
Combination of G-CSF with a chemotherapeutic agent for stem cell mobilization
Patent Number: 6162427This patent teaches that a more potent stimulation of hematopoietic stem cell mobilization can be achieved by combining G-CSF with cyclophosphamide, as opposed to administration of either alone.
Method of mobilizing stem cells with chemokine .beta.-8
Patent Number: 6713052This patent teaches ways of mobilizing hematopoietic stem cells using the chemokine know as beta-8. Mobilization may be performed for harvesting of stem cells from peripheral blood by leukopheresis, or it may be performed for the purposes of expanding the number of stem cells in circulation when there is a wound in the body that is attracting stem cells. Such a wound could be the lesion of...