Patents
PSCA: prostate stem cell antigen and uses thereof in pancreatic cancer
Patent Number: 7,485,296The current patent covers "A method for treating a patient having pancreatic cancer by inhibiting the growth of a pancreatic cancer cell expressing the Prostate Stem Cell Antigen (PSCA) protein as shown in SEQ ID NO: 2 in the patient, comprising contacting the pancreatic cancer cell with the monoclonal antibody 1G8 (ATCC No. HB-12612), or a fragment thereof that recognizes and binds PSCA as...
Inventors: Reiter; Robert E. (Los Angeles, CA), Witte; Owen N. (Sherman Oaks, CA), Saffran; Douglas C. (Los Angeles, CA), Jakobovits; Aya (Beverly Hills, CA)
Assignee: The Regents of the University of California (Oakland, CA); Agensys, Inc. (Santa Monica, CA)
Date of First Priority Issue: Monday March 10th, 1997
Enhanced growth of adult stem cells with Dkk-1
Patent Number: 7,485,460Although mesenchymal stem cells, or mesenchymal stromal cells (as some others call them), are in late stages of clinical development, there is still room for optimizing their therapeutic effects. For example, various groups have transfected MSC with genes such as nanog or bcl-2 or
Assignee: Tulane University Health Sciences Center (New Orleans, LA)
Date of First Priority Issue: Wednesday May 21st, 2003
Biomaterial derived from vertebrate liver tissue
Patent Number: 7,482,025This patent teaches the use of a decellularized liver matrix for induction of tissue growth, the tissue growth being mediated by the cells already residing in the patient, such as stem or progenitor cells. The first independent claim covers "A method for inducing the formation of endogenous tissue at a site in need of endogenous tissue growth in a warm-blooded vertebrate, the method...
Inventors: Badylak; Stephen F. (West Lafayette, IN)
Assignee: Badylak Stephen F. (West Lafayette, IN)
Date of First Priority Issue: Tuesday December 10th, 1996
Telomere-encoding synthetic DNA nanocircles, and their use for the elongation of telomere repeats
Patent Number: 7,482,332Telomeres are repeats of the TTAGGG sequence on the ends of chromosomes that progressively get shorter with each cell division, causing eventual cell senescence. The enzyme telomerase is important in cells that need to proliferate longer, for example memory T cells, or stem cells. It is a dream of many to induce telomerase activity in cells so as to be able...
Inventors: Kool; Eric T (Stanford, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA)
Date of First Priority Issue: Friday January 4th, 2002
Method of enhancing myogenesis by electrical stimulation
Patent Number: 7,483,749Stem cells act as part of the endogenous repair processes of the body. For example, after heart attacks specific populations of stem cells leave the bone marrow and are attracted to the heart, presumably to regenerate the injured myocardium. Interesting new stem cell populations such as the VSEL stem cell population have...
Inventors: Leonhardt; Howard J. (Weston, FL), Chachques; Juan C. (Paris, FR)
Assignee: Bioheart, Inc. (Sunrise, FL)
Date of First Priority Issue: Wednesday June 13th, 2001
Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor
Patent Number: 7,479,371This patent covers the use of stem cell growth factor concentrations as a means of diagnosing a leukemic condition. The main coverage of the patent is represented in the first independent claim, which covers:"A method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases wherein stem cell growth factor (SCGF) in an in-vivo sample is quantified, wherein the method...
Inventors: Ando; Kiyoshi (Chigasaki, JP), Hotta; Tomomitsu (Nagoya, JP), Ito; Chie (Isehara, JP), Sato; Hidenao (Tokyo, JP), Furuya; Akiko (Tokyo, JP), Shitara; Kenya (Tokyo, JP), Sugimoto; Seiji (Tokyo, JP), Kohno; Hiroaki (Sunto-gun, JP)
Assignee: Tokai University (Tokyo, JP)
Date of First Priority Issue: Tuesday April 9th, 2002
In vivo assay and molecular markers for testing the phenotypic stability of cell populations and selected cell populations for autologous transplantation
Patent Number: 7,479,367Autologous stem cell transplantation has given positive results in cardiac, hepatic, and various ischemic conditions. The current patent addresses the use of autologous chondrocyte populations for treatment of various cartilage disorders. Cartilage destruction is often seen in conditions such...
Inventors: Luyten; Frank (Kraainem, BE), De Bari; Cosimo (Leuven, BE), Dell'Accio; Francesco (Heverlee, BE)
Assignee: Tigenex N.V. (Leuven, BE)
Date of First Priority Issue: Wednesday October 6th, 1999
Method for enhancing keratinocyte stem cells
Patent Number: 7,476,538This patent covers methods of selecting keratinocyte stem cells and expanding them. As you can imagine, one of the major applications for keratinocyte stem cells is in the cosmetics area (assignee is L'Oreal).The patent covers A method for enriching keratinocyte stem cells (KSCs) from a sample of keratinocytes and KSCs, said KSCs having an expansion potential of at least 10.sup.9 after about...
Inventors: Hatzfeld; Jacques (Antony, FR), Fortunel; Nicolas (Breuillet, FR), Hatzfeld; Antoinette (Antony, FR)
Assignee: Centre National de la Recherche Scientifique (Paris, FR); L'Oreal (Paris, FR)
Date of First Priority Issue: Tuesday October 30th, 2001
Monoclonal antibodies to mesenchymal stem cells
Patent Number: 7,476,540This patent covers antibodies that bind to mesenchymal stem cells. The antibodies are deposited as hybridomas under accession numbers KCLRF-BP-000123, KCLRF-BP-000124 or KCLRF-BP-000125 at the Korean Cell Line Research Foundation (Cancer Research Institute, Seoul National University, College of Medicine, 28 Yongondong, Chongno-Gu, Seoul, 110-744, Korea). The antigen appears to be about...
Inventors: Song; Yeong-Wook (Seoul, KR), Yoo; Hyun-Jung (Busan, KR), Yoon; Sung-Soo (Seoul, KR), Park; Seonyang (Seoul, KR), Park; Weon-Seo (Goyang-si, KR), Kim; Dong-Jo (Seoul, KR), Lee; Eun-Bong (Seoul, KR)
Assignee: Seoul National University Industry Foundation (Seoul, KR)
Date of First Priority Issue: Tuesday January 10th, 2006
Protocols for making hepatocytes from embryonic stem cells
Patent Number: 7,473,555This patent covers the generation of mature hepatocytes from pluripotent stem cells (pluripotent I presume they mean to include iPS). The inventors cover a three step process by which they induce pluripotent stem cells to differentiate into endoderm cells, then induce endoderm to differentiate into hepatic progenitors, and lastly induces the hepatic progenitors to differentiate into mature...
Inventors: Mandalam; Ramkumar (Union City, CA), Faouzi; Saadia (Daly City, CA), Nadeau; Isabelle (San Francisco, CA), Pfendler-Bonham; Kristina (South San Francisco, CA), Rao; Namitha (San Jose, CA), Carpenter; Melissa K. (London, CA), Rambhatla; Lakshmi (Redwood Ci
Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Thursday April 27th, 2000