This patent covers the use of heterocyclic trialkyl ammonium-containing compounds for stimulation of bone marrow proliferation and differentiation after myeloablation or other insults to the hematopoietic stem cell compartment. The toxicity profile of the compounds appears favorable.
Data in the examples section demonstrates protection from cyclophosphamide destruction of the bone marrow, as well as radiation and several other models.
Other stimulators of hematopoiesis include acyl deoxyribonucleosides, polyamines, and immune stimulatory peptides.
View this patent on the USPTO website.
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