Protection of cardiac myocardium

Patent Number: 7,504,379

This patent has two sets of independent claims.  The first covers "method of increasing survival of blood vessels" and the second "method of reducing myocardial necrosis". 

Both of these aims are achieved by "administering to the patient a therapeutically effective amount of platelet derived growth factor, angiopoietin-2, and vascular endothelial growth factor."

The administration of such growth factors could theoretically synergize with other stem cell therapies, for example, Osiris's intravenous bone marrow mesenchymal stem cells (Prochymal) have been demonstrated to improve post-infarct healing.  It would be interesting to see if combination of PDGF, VEGF, and angiopoietin-2 together with Prochymal would be synergistic.

View this patent on the USPTO website.