Hematopoietic stem cell identification and isolation

Patent Number: 7,510,877

Date of First Priority Issue: Friday September 26th, 2003

Date Issued: Tuesday March 31st, 2009

Assignee: The Regents of the University of Michigan (Ann Arbor, MI)

Inventors: Yilmaz; Omer H. (Ann Arbor, MI), Kiel; Mark J. (Ann Arbor, MI), Morrison; Sean (Ann Arbor, MI), Iwashita; Toshihide (Ann Arbor, MI)

From Class: Type

Comments: No comments

The hematopoietic stem cell is the most well studied stem cell, being responsible for saving hundreds of thousands of lives through allowing the procedure of bone marrow transplant to become a reality. As far back as 1984, filings on hematopoietic stem cells can be found (#4,714,680).

The current patent has a new way of purifying hematopoietic stem cells from sources such as blood, cord blood, bone marrow, fetal liver and spleen. Specifically, the method covers purification for cells of the phenotype CD150+, CD48-, and CD244-. It makes me feel like an old guy...but i have no idea what these markers mean, so I have looked them up...

CD150 is the same thing as Signaling Lymphocyte Activation Molecule (SLAM), a membrane glycoprotein expressed on immune cells. This is also one of the main receptors for the measles virus.

CD48 is an adhesion molecule that acts as the ligand for CD2. CD48- CD150+ cells have been described in the mouse as having hematopoietic stem cell capabilities (Wilson et al. Cell 2008 Dec 12;135(6):1118-29).

CD244 is a receptor on NK cells that gives inhibitory signals.

View this patent on the USPTO website.

Added to StemCellPatents.com on Monday April 6th, 2009

Social & Bookmarking: