Human lineage committed cell composition with enhanced proliferative potential, biological effector function, or both; methods for obtaining same; and their uses
Patent Number: 6835566
Date of First Priority Issue: Monday February 23rd, 1998
Date Issued: Tuesday December 28th, 2004
Assignee: Aastrom Biosciences, Inc. (Ann Arbor, MI)
Inventors: Smith, Alan K. (Saline, MI); Smith, Douglas M. (Ann Arbor, MI); Mandalam, Ramkumar K. (Westland, MI)
From Class: Type
Comments: No comments
This patent teaches the generation of lineage-committed dendritic cell progenitors. This is important since the dendritic cell is a master controller of the immune response, being able to both stimulate responses as well as inhibit them. Dendritic cells can be made to stimulate responses through activation with various cytokines or toll like receptors, whereas they can also suppress responses when they are treated with cytokines such as IL-10 or TGF-b.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
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