Homologous recombination for universal donor cells and chimeric mammalian hosts
Patent Number: 5574205
Date of First Priority Issue: Tuesday July 25th, 1989
Date Issued: Tuesday November 12th, 1996
Assignee: Cell Genesys (Foster City, CA)
Inventors: Kucherlapati, Raju (Darien, CT); Koller, Beverly H. (Carrboro, NC); Smithies, Oliver (Chapel Hill, NC); Dubridge, Robert B. (Belmont, CA); Greenburg, Gary (San Carlos, CA); Capon, Daniel J. (Hillsborough, CA); Williams, Steven R. (San Francisco, CA); De R
From Class: Type
Comments: No comments
This patent covers generation of mice that lack MHC I and/or MHC II. Stem cell transplants are one of the transplants that the inventor believes can be performed with donor cells that lack MHC I and/or MHC II. Unfortunately the issue of rejection has to do not only with "major" histoincompatibility, but also with "minor" histoincompatibility.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
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