Homologous recombination for universal donor cells and chimeric mammalian hosts
Patent Number: 5413923
Date of First Priority Issue: Monday November 6th, 1989
Date Issued: Tuesday May 9th, 1995
Assignee: Cell Genesys, Inc. (Foster City, CA); Univ. of North Carolina at Chapel Hill (Chapel Hill, NC)
Inventors: Kucherlapati, Raju (Darien, CT); Koller, Beverly H. (Carrboro, NC); Smithies, Oliver (Chapel Hill, NC)
From Class: Type
Comments: No comments
This patent teaches how to genetically delete the MHC antigens in order to have stem cells and progeny of the stem cells that are capable of acting as universal donor cells. Although this technology is at face value very interesting, the fact that other antigens besides MHC cause rejection of tissue dampens enthusiasm for this approach. Additionally, the ability of recipient immune system to cause immune activation through indirect antigen presentation also is a cause of concern for efficacy of this approach.
View this patent on the USPTO website.
Added to StemCellPatents.com on Monday October 16th, 2006
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