Method for stimulating production of bone marrow cell growth factors using dithiocarbamates

Patent Number: 5169765

This patent teaches that dithiocarbamate and its analogues have the ability to stimulate bone marrow production of hematopoietic growth factors. Dithiocarbamate may be used according to the invention for stimulation of hematopoietic cells to produce growth factors, and subsequently the dithiocarbamate may be taken off the cells.

While this patent seems like a really interesting method of stimulating hematopoiesis, at least one paper suggests that dithiocarbamates may actually inhibit hematopoietic stem cells (_Pyatt DW et al. Dithiocarbamates inhibit hematopoiesis via a copper-dependent mechanism. Biochem Biophys Res Commun. 2000 Aug 2;274(2):513-8_.

View this patent on the USPTO website.