Stromal antigen-presenting cells and use thereof
Mesenchymal stem cells are known to possess a variety of immune modulatory activities such as suppression of allogeneic responses, as well as induction of T regulatory cells. Mechanisms include expression of IDO and HLA-G. Mesenchymal stem cells have been demonstrated effective in patients with heart failure and are clinically in trials for graft versus host disease.
The current patent teaches the use of mesenchymal... [Read more]
Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
This patent is a continuation of Blasticon's #7,138,275 covering a monocyte-derived stem cell that is capable of differentiating into islets, hepatocytes, and neurons. In the current patent the use of hepatic, or hepatic-like cells derived from these monocytes is covered.
The general coverage of the patent extends to generation and use of a cell capable of expressing albumin that is made by the differentiation of a CD-14 positive, CD-90 positive monocytic derived stem cell.
Covered uses including treatment of cirrhosis... [Read more]
Directed in vitro differentiation of marrow stromal cells into neural cell progenitors
This patent covers the generation of neurons from mesenchymal stem cells, or like the inventor calls them "mesenchymal stromal cells", which is the more politically correct way of naming them.
Very broad claims are issued, the first one being: "A method of producing a neural progenitor cell, said method comprising contacting an isolated bone marrow stromal cell with a compound that induces differentiation of said bone marrow stromal cell, wherein the compound is a cyclic AMP-stimulating compound that increases the... [Read more]
Progenitor cells from wharton's jelly of human umbilical cord
This patent covers methods of extracting an adherent mesenchymal-like stem cells from the Wharton's Jelly of the umbilical cord. The extracted cells are negative for MHC and are termed by the inventors human umbilical cord perivascular (HUCPV) cells. In the examples section the the cells are demonstrated to be capable of differentiating into osteocytes, chondrocytes, adipocytes, and myocytes.
The first independent claim covers "A method of obtaining a population of human umbilical cord perivascular (HUCPV) cells, comprising: (a) obtaining an excised blood vessel... [Read more]
View all stem cell patents
- Patent Spotlight - Stromal antigen-presenting cells and use thereof - 7,553,661
- Dedifferentiated, programmable stem cells of monocytic origin, and their production and use - 7,553,663
- Directed in vitro differentiation of marrow stromal cells into neural cell progenitors - 7,547,545
- Progenitor cells from wharton's jelly of human umbilical cord - 7,547,546
- Methods for identifying factors for differentiating definitive endoderm - 7,541,185
- Method of generating human retinal progenitors from embryonic stem cells - 7,541,186
- Method of expanding undifferentiated hemopoietic stem cells - 7,534,609
- Pregnancy-induced oligodendrocyte precursor cell proliferation regulated by prolactin - 7,534,765
- Growth and differentiation of adult muscle stem cells with activators or inhibitors of Wnt signaling - 7,541,183
- Angiogenically effective unit dose of FGF-2 and method of use - 7,541,333
- Stem cells and their use in transplantation - 7,537,756
- Methods of producing pancreatic hormones - 7,534,608
- Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices - 7,531,505
- Double nuclear transfer method and results thereof - 7,531,715
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Methods of recruiting fibroblasts by administering G-CSF - 7,531,510
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- Neuronal progenitors from feeder-free human embryonic stem cell culture - 7,531,354
- Clusterin-mediated inhibition of apoptosis via stromal bone marrow cell delivery to a cardiac site - 7,524,490
- Blood and cell analysis using an imaging flow cytometer - 7,522,758
- Implantable cell/tissue-based biosensing device - 7,519,409
- Method of isolating human neuroepithelial precursor cells from human fetal tissue - 7,517,521
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Dedifferentiated, programmable stem cells of monocytic origin, and their production and use - 7,517,686
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- Feeder independent extended culture of embryonic stem cells - 7,514,260
- Platelet-derived growth factor protection of cardiac myocardium - 7,514,261
- Isolation and transplantation of retinal stem cells - 7,514,259