Category: Neural (28)
IL-10 in healing of nerves
Sheffield, UK - There seems to be some connections between the immune system and various stem cell niches. For example, while the role of the stromal cells is to provide nutrients for the bone marrow hematopoietic stem cells, these cells also play anti-inflammatory functions. In some situations activations of enzymes associated...
Usefulness of Amniotic Fluid Stem Cells
Punjab, India - Readers of ours may remember the discussion we had on the Wake Forest finding regarding amniotic stem cells. In a recent paper (Rehni et al. Amniotic fluid derived stem cells ameliorate focal cerebral ischaemia-reperfusion injury induced behavioural deficits in mice. Behav Brain Res. 2007 May 26) the utility of these...
Remyelination by Stem Cells
[Watch the Video] This video describes the use of Schwann cell precursors to induce remyelination. Presented is a neat model of demyelination and specifics about how to use it to evaluate regenerative stem cell populations. This approach is useful for developing therapeutics for treatment of diseases such as multiple sclerosis.
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Immortal Neural Stem Cell
Milan, Italy -
Immortalized stem cell lines are great tools for drug discovery in that they can be used for screening of chemical libraries for compounds that induce either self renewal or differentiation along a specific lineage. Therapeutically, despite oncogenic potential, differentiated stem cell lines have been used in
Antipsychotic modulation of stem cells
Sapporo, Japan – Patients with schizophrenia are usually treated with antipsychotic drugs. Typical or atypical antipsychotics such as clozapine and olanzapine have been utilized with various degrees of success. The mechanisms of actions of these drugs are not completely known, although the majority do have dopamine modulatory activity. In a recent publication (Kurosawa et al...
ALS Therapy by Stem Cells
Treatment of MS by Stem Cells
HIF involved in mesenchymal to neural differentiation
Caen cedex, France - The identification of molecular signals associated with cellular differentiation is important from a drug development perspective. Recently, a paper was published describing mechanisms of mesenchymal stem cell differentiation to neural cells (Pacary et al. Crosstalk between HIF-1 and ROCK pathways in neuronal...
Coaxing ES cells to neurons
Hong Kong, China - Numerous groups are currently working on protocols for induction of differentiation of embryonic stem cells into specific cell types that are therapeutically useful. One logical method of stimulating differentiation involves co-culture with cells that would appear to have an "inductive" effect on the undifferentiated cell. On the one hand, numerous groups use methods...
HSP antiinflammatory
San Francisco, California - Heat shock proteins are conventionally thought of as molecular chaperones that function intracellularly. Immunologically, heat shock proteins are known to bind various tumor antigens and can be used as adjuvants. The properties of adjuvants include non-specific activation of innate immunity. It was found that various heat shock proteins stimulate macrophage and...