Category: Neural (28)
Neural proliferation after injury
Miami, Florida - Although it is reported that the brain can repair itself after injury, detailed examination of this is still somewhat lacking. In a nicely designed study (Urrea et al. Widespread cellular proliferation and focal neurogenesis after traumatic brain injury in the rat. Restor Neurol Neurosci. 2007;25(1):65-77), proliferation of various brain areas was assessed following...
Importance of Injury in Stem Cell Neurorepair
Milano, Italy - In various pathological conditions injured tissue attracts endogenous stem cells through release of various factors. This is known, for example, in the area of myocardial infarction where circulating levels of stem cells increase in the peripheral blood of patients after heart attacks. Theoretically, the idea is that the ischemia and tissue damage release systemic factors...
In vitro ALS model
Cambridge, Massachusetts - Generation of in vitro models of human diseases allows utilization of high-throughput screening, as well as isolated molecular dissection of events in order to identify targets for intervention. A recent paper (Di Giorgio et al. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model Nat Neurosci...
Neupogen: From White Cell to White Matter
Chiba, Japan - The clinical use of G-CSF (Neupogen) has allowed for mobilization of stem cells in the peripheral blood stem cell transplant setting, as well as a means of accelerating hematopoietic recovery in a variety of settings. A recent paper suggests that mobilization of stem cells using G-CSF may be useful not only for hematopoietic indications but also for inducing repair post...
Sugar in the brain
Tokyo, Japan - It is known that a wide variety of factors are capable of inducing neurogenesis in the adult brain. For example, post-stroke neurogenesis is known to be at least partially dependent on eryothropoietin signaling (Tsai et al. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006 Jan 25;26(4):1269-74.)Saturday March 17th, 2007 @ 15:25:29 EST
Not all mitogens are the same
Cambridge, UK - Neurons communicate with each other by exchanging electrical signals through axons, or otherwise called nerve fibers. These axons are insulated by the phospholipid myelin, which acts as an insulator. Myelin is deposited on neurons of the peripheral nervous system by Schwann cells, and on neurons of the central nervous system by oligodendrocytes. Both Schwann cells and...
1 Comment
Skin Stem Cells for Nerve Regeneration
Milan, Italy - One approach to nervous system repair after injury involves implantation of "guide tubes", which has the name implies, preferentially induces regenerating neural cells to migrate into a desired direction. The question, of course, is what type of neural progenitors should one use in conjunction with such guide tubes. Embryonic stem cells have the disadvantage of potentially...
G-CSF of Blood and Brain
Loma Linda CA- We at StemCellPatents.com have described in various patents the relationship between hematopoietic stem cells and neural stem cells. Stunning examples include the ability of neurons to stimulate hematopoiesis, Patent # 6897060, the ability of the same hypoxic conditions that promote hematopoietic stem cell...
1 Comment