Category: Migration (30)
Why Sorted CXCR4+ and CXCR4- Stem Cells Have Similar Engraftment
[Watch the Video] This video reviews data that explains why CXCR4+ stem cells and CXCR4- stem cells home with similar efficiency to the bone marrow. The answer is that the CXCR4 antibody actually blocks signalling, and that CXCR4- cells actually contain intracellular stores of...
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Accelerating Mesenchymal Stem Cell Migration
Beijing, China -
Mesenchymal stem cells are currently being explored by companies such as pluristem for the acceleration of bone marrow hematopoietic stem cell engraftment after transplantation. In a recent study (Shi et al. Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in
Seaweed mobilization of stem cells
Hobart, Australia - Stem cell mobilization from the bone marrow is clinically performed by administration of cytokines such as G-CSF in order to collect peripheral blood stem cells, primarily for the purposes of bone marrow transplant. Other newer uses include the mobilization of stem cells in order to accelerate healing of cardiac infarcts, as well as induction of angiogenesis by...
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Calling All Stem Cells !!!
Minneapolis, Minnesota - It is known that subsequent to cardiac infarction, various cytokines are produced by the injured myocardium that mobilize endogenous stem cells from the bone marrow into systemic circulation, and specifically "calling" them to home to the ischemic tissue. Unfortunately, this process occurs only to a small extent and full repair of the myocardium after injury...
Endotoxin decreases circulating EPC
Vienna, Austria - Circulating endothelial progenitor cell levels have been reported to increase with exercise, smoking cessation, as well as taking statin drugs...amongst other things. In a recent paper it was demonstrated that endotoxin induces a temporary (24 hr) decrease in the number of circulating endothelial progenitors (Mayr et al. Effects of low dose endotoxemia on endothelial...
N-formyl peptides and Mesenchymal Stem Cells
New Orleans, Louisiana – One of the common themes in the study of stem cells is their ability to home into areas of damaged tissue. It is known that factors generated during hypoxia, such as stromal derived factor-1 generally attract stem cells, however other signals generated during injury that attract stem cells are less well understood. N-formyl peptides are cleavage products of...
Stem Cells Follow The Music
Frankfurt, Germany - One of the main issues with stem cell therapy is induction of their migration to area of need. In a report published recently (Aicher et al. Low-Energy Shock Wave for Enhancing Recruitment of Endothelial Progenitor Cells. A New Modality to Increase Efficacy of Cell Therapy in Chronic Hind Limb Ischemia. Circulation. 2006 Dec 4) a novel way of inducing migration...
Lipid Attraction of Stem Cells
Montreal, Canada -
Stromal Derived Factor (SDF)-1 is one of the cell-to-cell communication signals that is involved in stem cells (mesenchymal and hematopoietic) migration to sites of injury. In a recent paper, (Meriane et al. Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling... Rehovot, Israel –
It is known that exosomes, small, viral-sized particles are used by the immune system to communicate with itself.
In a recent paper published by Lapidot’s group (Kalinkovich et al. Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells. Cancer Res. 2006 Nov... Singapore-
Scientists at Viacell announced the ability of unrestricted somatic stem cells (USSC) to enhance migration and repopulation of hematopoietic stem cells in an animal model through secretion of the stem cell chemotactic factor SDF-1.
Chan et al in a publication titled "ENHANCED IN VIVO HOMING OF UNCULTURED AND... 2 Comments
Exosomes and Stem Cells...
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Stem Cells Follow The Leader