Category: Migration (30)
Cardiac Stem Cell Migration Dependent on p38
Wuhan, China -
Many tissues have tissue resident stem cells. Although not in high numbers, these stem cells have nevertheless been demonstrated to play at least some role in regeneration after injury. Stem cells in tissues can be isolated by their side population characteristics, or by their expression of
Tumors Calling Stem Cells
Galway, Ireland - The possibility of stem cells inducing tumor cell differentiation and thus reducing pathological potential has been speculated by numerous scientists. However, few studies have actually demonstrated that intravenously administered stem cells actually home to the area of tumor localization. Recently it was published (Dwyer et al Monocyte chemotactic protein-1...
More Seaweed Mobilization
Calgary, Canada -
The people behind the company StemTech (multilevel marketing of a product called StemEnhance which supposedly increases circulating stem cells by mobilization) have published a paper describing possible mechanism of action for their stem cell mobilizer
(Jensen et al. Mobilization of human CD34CD133 and
Complement Needed for G-CSF Mobilization
[Watch the Video] The possibility of the immune system doing other things than killing pathogens has been suggested by people like Polly Matzinger for decades. In this paper the authors identified that the C5 component of complement is strictly needed for G-CSF induced mobilization.
Stem Cell Migration into Non-Injured Tissue
[Watch the Video] This video describes the paper by Fred Gage's group in which adult stem cells were demonstrated to migrate into CNS tissue and contribute to chimeric microglia and astrocyte cells but not endothelium. This supports the possibility that stem cells may cross the blood brain barrier in absence of inflammation.
Parathyroid Hormone Mobilizes Stem Cells
Boston, USA - Stem cell mobilizing agents are conventionally used to increase the number of circulating stem cells in peripheral blood so that these stem cells can be harvested and used for transplantation, either in an autologous, or allogeneic manner. Nutritional companies have capitalized on the possibility of mobilizing stem cells by various supplements so as...
Hyaluronic Acid Mediated Mesenchymal Stem Cell Migration
Much is known about CD34+ stem cell migration to areas of hypoxia due to secretion of SDF-1 (CXCL12) by the hypoxia tissue. Migration towards the CXCL12 gradient has been documented in diverse situations ranging from post-myocardial infarction CD34 mobilization to homing of hematopoietic...
Stroke Calls Stem Cells
Nice, France - It is known that after myocardial infarction stem cells exit the bone marrow and enter systemic circulation, possibly as a response to chemoattractants released by injured myocardium. In a recent study (Dunac et al. Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization. J Neurol. 2007...
Stem Cell Cancer Therapy
Bratislava, Slovakia - Various types of stem cells are known to home specifically into neoplastically transformed tissue. In a recent paper (Kucerova et al. Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy. Cancer Res. 2007 Jul 1;67(13):6304-13) this property was leveraged in order to provide...
Telling Mesenchymal Stem Cells Where to Go
Birmingham, Alabama, USA -
Stem cell migration is an important issue. In situations like bone marrow transplantation for hematpoietic reconstitution, the hematopoietic stem cells are "told" to home to the bone marrow of the recipient by virtue of molecules such as SDF-1 which are...