News Posts
BMP-2 Induces Fat Stem Cells to Become Cartilage
Xian, China – Fat derived stem cells offer numerous therapeutic possibilities since they are available large amounts from autologous starting material. In a recent paper (Wei et al. Regulation of adipose-derived adult stem cells differentiating into chondrocytes with the use of rhBMP-2. Cytotherapy. 2006;8(6):570-9.) it was demonstrated that culturing of fat derived stem cells with the...Thursday December 7th, 2006 @ 17:57:34 EST
Stem Cells Follow The Music
Frankfurt, Germany - One of the main issues with stem cell therapy is induction of their migration to area of need. In a report published recently (Aicher et al. Low-Energy Shock Wave for Enhancing Recruitment of Endothelial Progenitor Cells. A New Modality to Increase Efficacy of Cell Therapy in Chronic Hind Limb Ischemia. Circulation. 2006 Dec 4) a novel way of inducing migration was...Thursday December 7th, 2006 @ 02:56:05 EST
Glucocorticoid Inhibition of Skin Cancer
Chicago Illinois - Chebotaev et al reported today that overexpression of glucocorticoid receptor in the skin of mice inhibits carcinogenesis. The paper (The tumor suppressor effect of the glucocorticoid receptor in skin is mediated via its effect on follicular epithelial stem cells. Oncogene. 2006 Dec 4) provided evidence suggestive of the role of follicular epithelial stem cells in cancer...Thursday December 7th, 2006 @ 02:44:15 EST
Growth Hormone Double Blind Hematopoiesis Study
Surrey, UK – It is always nice to see patented concepts verified by scientific publications, especially when it is in clinical trials settings. Readers of StemCellPatents.com will know that US patent # 6348444 assigned to Applied Research Systems ARS Holding N.V. (A wholly owned subsidiary of Serono) covers methods of...Tuesday December 5th, 2006 @ 21:09:10 EST
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Lipid Attraction of Stem Cells
Montreal, Canada - Stromal Derived Factor (SDF)-1 is one of the cell-to-cell communication signals that is involved in stem cells (mesenchymal and hematopoietic) migration to sites of injury. In a recent paper, (Meriane et al. Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling...Monday December 4th, 2006 @ 19:45:58 EST
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Sticking it to Infarcted Myocardium
San Francisco, CA - Lee et al published (Antibody Targeting of Stem Cells to Infarcted Myocardium. Stem Cells. 2006 Nov 30; [Epub ahead of print]) a novel technique of increasing the concentration of stem cells to specific injured tissue. The investigators generated an antibody-like molecule of which one end binds to stem cells (well the actual antibody, anti-CD45) binds to many cells...Monday December 4th, 2006 @ 12:35:41 EST
Stem Cells Come in All Shapes and Sizes
Louisville, KY – Stem cells from adult sources (non-embryonic) are generally believed to be restricted in differentiation potential. However, there are several reports of stem cells from bone marrow and cord blood that express makers of pluripotency. For example, in 2004 Prockop’s group from Tulane reported that if one incubates early passaged human bone marrow derived mesenchymal cells...Friday December 1st, 2006 @ 12:51:44 EST
ES cells to Hepatocytes
Bethesda MD - Readers of StemCellPatents.com are familiar with the patent of Loren Field which teaches that tissue-specific promoters can drive expression of markers from embryonic stem cell cultures so as to be able to selectively "fish out" stem cells that are starting to commit to a specific lineage. In a recent paper (Heo J...Thursday November 30th, 2006 @ 20:13:49 EST
Oral Arguments for Obviousness
The issue of what improvements to existing technologies are "non-obvious" and therefore deserve awarding of patents is critical for those of us involved in biotechnology. Oral arguments for the first Supreme Court Case in more than 30 years examining this issue, KSR v Teleflex, were heard yesterday. The main issue at hand is...Wednesday November 29th, 2006 @ 21:35:03 EST
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Exosomes and Stem Cells...
Rehovot, Israel – It is known that exosomes, small, viral-sized particles are used by the immune system to communicate with itself. In a recent paper published by Lapidot’s group (Kalinkovich et al. Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells. Cancer Res. 2006 Nov 15;66(22):11013-20) circulating exosome-like particles that...Wednesday November 29th, 2006 @ 19:26:16 EST
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