News Posts
Fat to endothelium
Aachen, Germany - The use of adipose tissue for regenerative medicine is particularly exciting since large amounts of autologous stem cells can be procured in this manner with minor discomfort to the patient. A recent publication (Wosnitza et al. Plasticity of human adipose stem cells to perform adipogenic and endothelial differentiation. Differentiation. 2007 Jan;75(1):12-23...Thursday January 25th, 2007 @ 11:08:16 EST
N-formyl peptides and Mesenchymal Stem Cells
New Orleans, Louisiana – One of the common themes in the study of stem cells is their ability to home into areas of damaged tissue. It is known that factors generated during hypoxia, such as stromal derived factor-1 generally attract stem cells, however other signals generated during injury that attract stem cells are less well understood. N-formyl peptides are cleavage products of...Tuesday January 23rd, 2007 @ 11:35:52 EST
Adult Neural Precursors for Parkinson's
Seoul, South Korea - Fetal cell therapy has been previously used in clinical trials for treatment of Parkinson's Disease, although with little success (Olanow et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol. 2003 Sep;54(3):403-14). It a recent paper (Shim et al. Generation of Functional Dopamine Neurons from Neural...Monday January 22nd, 2007 @ 11:04:52 EST
1 Comment
1 Comment
EGF-Tethered Matrices
Boston, MA - The utilization of mesenchymal stem cells for healing of tissue defects, or for example, bone fractures, best occurs when the stem cells are implanted using a supportive matrix. Although a wide variety of such matrices are known to exist, one of the major problems is how to have the stem cells not only grow on the matrix, but also exhibit properties similar as if the stem...Thursday January 18th, 2007 @ 11:53:39 EST
Amniotic Stem Cells: Old News
Winston-Salem, North Carolina - Readers of StemCellPatents.com are familiar with the fact that amniotic fluid contains stem cells with pluripotent activity useful for numerous applications, including regeneration of cartilage. A press release that made national...Thursday January 11th, 2007 @ 02:21:32 EST
Replacing fetal calf serum
Mumbai, India - It is commonly known that growing almost any mammalian cell in culture requires the addition of fetal calf serum to the culture media. Unfortunately, fetal calf serum contains numerous xenogeneic proteins, which elicit various inflammatory responses when administered clinically. Accordingly, there is a big push in the industry to generate alternatives to fetal calf serum for...Tuesday January 9th, 2007 @ 21:42:39 EST
3 Comments
3 Comments
Skin Stem Cells for Nerve Regeneration
Milan, Italy - One approach to nervous system repair after injury involves implantation of "guide tubes", which has the name implies, preferentially induces regenerating neural cells to migrate into a desired direction. The question, of course, is what type of neural progenitors should one use in conjunction with such guide tubes. Embryonic stem cells have the disadvantage of potentially...Friday January 5th, 2007 @ 18:39:57 EST
Embryonic to Mesenchymal Stem Cell Differentiation
Madison, Wisconsin - ES cells are very useful since they can be genetically modified to overexpress specific genes, or alternatively, specific genes can be deleted. In a recent publication (Trivedi et al. Simultaneous generation of CD34 primitive hematopoietic cells and CD73 mesenchymal stem cells from human embryonic stem cells cocultured with murine OP9 stromal cells.Exp Hematol. 2007...Wednesday January 3rd, 2007 @ 11:14:13 EST
Chromatin Modification for Hematopoietic Stem Cell Expansion
Chicago, Illinois - The ability to expand autologous hematopoietic stem cells ex vivo, while retaining hematopoietic reconstitutive activity in vivo would allow cell therapy for many types of leukemias and cancers in patients lacking donors. Unfortunately, to date, there has been very little success at ex vivo expansion of hematopoietic stem cells that can successful re-establish blood-forming...Saturday December 23rd, 2006 @ 20:21:37 EST
2 Comments
2 Comments
Education by fat
Suita-shi, Japan - It is known that adipose tissue contains several interesting stem cell types. Although clinical trials are currently ongoing using adipose derived stem cells, little work is being performed using adipose stem cells to "educate" other types of stem cells. In a recent paper(Yamada Y et al. A novel approach for myocardial regeneration with educated cord blood cells...Thursday December 21st, 2006 @ 01:58:47 EST