News Posts
Mouse to Primate XenoStem Transplant
Saint-Mande, France - The ability of various stem cell types to be immune privileged is well known. For example, it is known that mesenchymal stem cells can act as veto cells under specific conditions. While mesenchymal stem cells are derived usually from the bone marrow, and it would make sense for them to suppress immune...Monday February 12th, 2007 @ 19:22:44 EST
New BMPs for bone healing
Chicago, Illinois - One of the first areas of medicine in which regenerative technologies have been applied is the acceleration of bone healing. Although most bones heal naturally, in certain situations (both fracture and host specific) healing does not occur properly. The bone morphogenic proteins (BMPs) are a family of growth factors that play important roles in embryogenesis, as well...Friday February 9th, 2007 @ 12:11:23 EST
FGF-2 reduces SDF-1
Bethesda, MD - Numerous types of leukemias are associated with secretion of the cytokine fibroblast growth factor-2 (FGF-2). These leukemias are also associated with splenomegaly, hepatomegaly, and extramedullary hematopoiesis. In a recent paper (Nakayama et al. Effect of fibroblast growth factor 2 on stromal cell-derived factor 1 production by bone marrow stromal cells and hematopoiesis. J...Thursday February 8th, 2007 @ 10:41:06 EST
MSC as Veto Cells II
Baltimore, MD - It is known that mesenchymal stem cells have veto-like properties. Essentially the veto cell inactivates, either through killing or induction of anergy, a cell that reacts against it. Theoretically, if the mesenchymal stem cells have veto-like properties, then this veto activity should be recognized in vivo by...Wednesday February 7th, 2007 @ 21:01:14 EST
MSC = Veto cells
Duarte, CA - It is known that mesenchymal stem cells are potent immune modulators. The methods by which they inhibit various inflammatory reactions include production of immune suppressive cytokines such as IL-10, induction of tryptophan depletion using the enzyme IDO, and providing signal 1 in absense of costimulation. The...Wednesday February 7th, 2007 @ 11:42:44 EST
Stem Cell T Stimulation
Bethesda, Maryland - The return of ex vivo expanded T cells into an "empty compartment" has been used successfully by Steven Rosenberg and various researchers at the NIH for treatment of cancer. Essentially the idea is that when T cells are placed into a compartment that is lymphodepleted, then the T cells will proliferate by homeostatic expansion and be able to kill targets in absence of...Monday February 5th, 2007 @ 10:56:21 EST
Limb Ischemia: Follow the leader
Nagoya, Japan - Readers of StemCellPatents.com will be familiar with a previous publication stating that cord blood derived stem cells can accelerate reconstitution of hematopoietic stem cells. This concept of one type of stem cell helping other types of stem cells was demonstrated in a recent paper by Kajiguchi et al (Safety and...Thursday February 1st, 2007 @ 11:08:53 EST
Liver regeneration by inhibiting the inhibitor
Kayseri, Turkey - Readers of StemCellPatents.com will be familiar with patents describing the inhibition of TGF-beta as a means of stimulating stem cell proliferation. Essentially, it is known in the hematopoietic system at least, that autocrine production of TGF-beta by stem cells keeps them in a quiescent state. Accordingly if...Tuesday January 30th, 2007 @ 11:12:02 EST
Not all mitogens are the same
Cambridge, UK - Neurons communicate with each other by exchanging electrical signals through axons, or otherwise called nerve fibers. These axons are insulated by the phospholipid myelin, which acts as an insulator. Myelin is deposited on neurons of the peripheral nervous system by Schwann cells, and on neurons of the central nervous system by oligodendrocytes. Both Schwann cells and...Friday January 26th, 2007 @ 21:22:27 EST
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Adult stem cells: Fat to brain
Tokyo, Japan - [Watch the Video] The ability to adipose derived stem cells to differentiate into a variety of tissues is well known. Primarily, adipose derived stem cells are mesenchymal-like, however, they are also known to differentiate into endothelial cells. Some authors have published that not only can adipose derived stem...Friday January 26th, 2007 @ 10:41:14 EST