Liver Failure Regeneration: Its the quality of the injury that matters
Houston, Texas-
There are numerous clinical examples of adult stem cells helping people or animals with liver failure. One of the ways in which mesenchymal stem cells help in liver failure is by their ability to produce IL-10 in response to stellate cell generated IL-6, and through this process the mesenchymal stem cell inhibits collagen deposition by the stellate cell. Of course, the other potential mechanisms include the direct differentiation of stem cells into hepatocytes.
One recent study (Kienstra et al. Injury Mechanism Dictates Contribution of Bone Marrow-Derived Cells to Murine Hepatic Vascular Regeneration. Pediatr Res. 2007 Nov 16;) evaluated the specific types of injury that induces bone marrow cells to help regenerate liver through producing new blood vessels.
The scientists used 2 injury systems: partialy hepatectomy (ie cutting out a chunk of the liver) and administration of a hepatotoxin. In order to see stem cells, the scientists administered label bone marrow stem cells into mice that recieved lethal doses of radiation so that their hematopoietic system becomes all labeled.
Labeled cells participated in the formation of new blood vessels in the animals that recieved hepatotoxin but not animals which recieved hepatectomy. More labeled stem cells were seen in the area that appeared more damaged histologically, implying that the cells were some how recruited to damaged areas.
This study suggests that only specific types of injuries induce chemoattraction of hematopoietic stem cells, and that for other types of liver injuries it may be more worthwhile to examine different stem cell types.
Social & Bookmarking:
4 Comments | Add Comment
Jackie said...
Why dont you go to the www.pubmed.com website and type in your searches?
If I had hepatitis i would go to www.cellmedicine.com and try to get treated with stem cells. They are the only ones who knkow what they are doing.
Interferon, ribavarin, etc have good effects but to accelerate regeneration the easiest is using your own stem cells, like Cellmedicine.
Andrew Bluck said...
Look a the new work describing stellate cells, the cell that cause liver failure, are stopped by mesenchymal stem cell production of proteins that block inflammation https://www.stemcellpatents.com/news-show-241
Joseph Limm said...
I am curious about animal studies in liver failure, sometimes animal studies are stronger than human studies since these are performed under defined conditions. How many humans do you know that are inbred?
Add Comment
You must be signed-in to add your comments.
Sign-in now or Join the StemCellPatents.com Community for free.
Mary Price said...
Where can I find the clinical results about the human studies published? And does this procedure work with people who are infected with Hepetitis C ?