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Last week a paper was published demonstrating anti-fibrotic effects of mesenchymal stem cells derived from Wharton's Jelly.  Given that Osiris's bone marrow MSC product is anticipated to attain regulatory approval sometime next year, it will be interesting to watch the expansion of universal donor stem cell uses to other fields besides GVHD.

Novartis was granted a patent, #7,541,333, covering the use of FGF-2 for heart failure.  It will be interesting to see whether FGF-2 will be synergistic with angiogenesis promoting stem cells.  A new patent was added to the field of stem cell expansion with Pluristem being awarded #7,534,609 covering their stromal feeder-based bioreactor.  In the area of expansion another patent was issued, #7,541,183, disclosing uses of wnt-family molecules for manipulation of muscle progenitor cells in vitro. 

Stem Cell Therapeutics was issued #7,534,765 expanding their portfolio of IP covering pharmacologically applicable molecules for modulation of the endogenous stem cell compartment.

In the area of embryonic stem cells Novocell was issued another stellar patent, #7,541,186, covering methods of screening for compounds that induce endodermal differentiation.  Induction of retinal cell differentiation using a 2 step process was disclosed in #7,541,186.

 


Angiogenically effective unit dose of FGF-2 and method of use
 
 
Patent Number: 7,541,333

Stimulation of therapeutic angiogenesis offers great potential, not only for the obvious conditions such as critical limb ischemia and angina, but also for other indications post-stroke recovery and liver failure.  Methods of stimulating angiogenesis...[Read More]

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  Pulmonary Fibrosis Treated by Mesenchymal Stem Cells

Monday June 8th, 2009 @ 13:44:53 EST

Melbourne, Australia -

Systemic administration of stem cells is usually associated with preferential localization into the lung and liver.  Lung conditions such as acute respiratory distress syndrome have no cure with exception of transplantation, which is limited to a small number of patients.  The rationale of using mesenchymal...[Read More]

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