Class: Differentiation (190)
Use of neutral soluble glucan preparations to stimulate platelet production
Patent Number: 5488040beta.(1-3) glucan is used clinically as an immune stimulator. This patent teaches that beta glucan can be used to stimulate production of platelets by acting at the level of the hematopoietic stem cell. Beta glucan's mechanism of doing this appears to be currently unknown. Given the wide availablity and safety profile of beta glucan, this patent is useful for clinical development if...
Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture, methods for assaying the effect of substances on lineage-specific cell production, and cell compositions produced by these cultures
Patent Number: 6667034This patent covers ways of ex vivo stimulation of bone marrow and other hematopoietic cells so that after transplantation they may engraft faster. Some of the methods thought in the patent include ways of stimulating production of specific blood cell lineages that may be more important for the specific condition being treated by hematopoietic stem cell transplantation.
Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture
Patent Number: 5635386This patent provides culture conditions for in vitro pushing stem cells of the hematopoietic lineage to differentiate into various blood cells. This patent is useful for generation of "off the shelf" cells if a method is figured out how to "de-immunogenize" the cells.
Method for treating thrombocytopenia
Patent Number: 5126325This patent covers the use of B cell differentiation factor (BCDF) for treatment of thrombocytopenia. This may be interesting if the BCDF is still not characterized. It may be an interesting new way of stimulating hematpoietic stem cells to preferentially go towards the path of a specific lineage. I do have a feeling, however that the BCDF... This patent covers ways of generating a molecule that has granulocyte colony stimulating activity. It may be that this molecule is similar to G-CSF which is currently sold as "Neupogen" by the company Amgen. This patent covers the discover that follicle stimulating hormone releasing protein (FRP) can potentiate the activity of erythropoitin in terms of induce erythropoiesis. The patent covers this concept from three perspectives in its three independent claims. The first perspective is "a method for determining the erythrodifferentiation-potentiating capacity of hematopoietic stem... Disclosed is a novel peptide that is useful for terminally differentiating leukemic cells. This peptide could be generally used for luekemia therapy, but should also be considered in combination with some other differentiation inducing agents such as retinoic acid. This patent covers hematopoietic stem cell stimulatory peptides and proteins that are analogs of pluripotent G-CSF. These compounds are useful for stimulation of hematopoiesis after ablation with radiotherapy or chemotherapy. TGF-beta is a cytokine with numerous anti-inflammatory functions. The importance of TGF-beta at controlling inflammation is seen not only in its ability to prevent autoimmunity in several animal models, but also by the fact that tumor cells secrete large quantities of it in order to escape immune-mediated killing.
This patent teaches... This patent teaches how to make a hematopoietic-stimulatory substance through taking out blood, extracting monocytes and macrophages, culturing them with a glycoprotein from urine, and collecting/concentrating the resulting composition, which is useful for stimulating the proliferation and differentiation of human granulopoietic stem cells. This may be an interesting way to generate growth...
Method of producing a polypeptide having human granulocyte colony stimulating factor activity
Patent Number: 5994518
Potentiation of erythropoiesis
Patent Number: 5032507
Polypeptide capable of differentiating and maturing malignant cells into normal cells or capable of accelerating the formulation of erythroblasts
Patent Number: 5847078
Analogs of pluripotent granulocyte colony-stimulating factor
Patent Number: 6004548
Inducing granulocyte production or B cell production in peripheral blood by TGF-.beta.
Patent Number: 5529982
Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells
Patent Number: 4342828