Class: Differentiation (190)
Method of inducing and maintaining neuronal cells
Patent Number: 6686198This patent teachs how to induce neural differentiation of stem cells through activation of the activin receptor associated pathways. One wonders if this patent is also applicable to bone marrow stem cells, or bone marrow stem cells induced to dedifferentiated by epigenetic modification.
Methods for differentiating neural stem cells to glial cells using neuregulins
Patent Number: 6033906This patent covers ways of generating glial cells in vitro for in vivo use. Several growth factors and culture conditions are provided.
Neuronal uses of BMP-11
Patent Number: 6340668The bone morphogenic proteins (BMPs) are able to stimulate various regenerative capabilities, including in the hematopoietic system, and especially in cartilage and bone. This patent teaches that BMP-11 is able to increase survival of neurons both in vitro and in vivo. This patent is useful for stimulation of neuronal stem cells, as well as for culture of neurons...
Method for production of neuroblasts
Patent Number: 6020197This patent covers the induction of differentiation of neural stem cells into various committed neuronal lineages. The patent provides FGF-2 for expansion of neural cells and stem cells, as well it provides various oncogenes which may be used for their immortalization.
Method for production of neuroblasts
Patent Number: 5766948This patent teaches how to generate a type of multipotential neural stem cell. These stem cells are extracted from embryonic sources. This patent may be useful for the treatment of a variety of neurodegenerative diseases.
Method of inducing cellular differentiations and altering cell phenotype using ceramide analogs
Patent Number: 5369030Ceramides are generated from membrane components by the enzyme sphingomyelinase. The importance of ceramides in cell biology is noted by their pro-apoptotic activity in certain cells, as well as ability to induce differentiation. This patent teaches that certain ceramides may be used to guide differentiation of stem cells into various lineages. It may be possible the through taking the...
Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-.beta. super family growth factors
Patent Number: 6001654This patent teaches how to induce the differentiation of neural stem cells into either neurons or smooth muscle cells by treatment with proteins that belong to the transforming growth factor beta superfamily.
In-vitro-derived human neutrophil precursor cells
Patent Number: 5955357This patent covers the differentiation of hematopoietic stem cells into neutrophil stem cells. The neutrophil stem cell is a type of cell that gives rise primarily to neutrophils upon further differentiation.
Method for the preparation of in vitro-derived human neutrophil precursor cells
Patent Number: 5700691This patent teaches how to differentiate hematopoietic stem cells into a type of stem cell that is committed to the neutrophil lineage. These "committed" stem cells may be administered into a neutropenic patient until endogenous neutrophils rebound.
Methods and compositions for obtaining mature dendritic cells
Patent Number: 7,198,948Dendritic cells are the most potent antigen presenting cell of the immune system. Essentially, they "tell" T cells what to attack and what not to attack. The first inventor of the current patent, Ralph Steinman is considered the discoverer of the dendritic cells. The patent covers a method of making dendritic cells from stem cells. According to the claims, the method involves...