Category: Embryonic (11)
Allogeneic rejection of embryonic stem cells
Nara, Japan -
Seeing stem cell therapy as sources of cytokines or angiogenic factors allows the possibility that the stem cell will eventually be rejected but the therapeutic effect will remain. For example, mesenchymal stem cells are known to secrete various immune modulatory factors, such as soluble HLA-G, which allows them to suppress...
"I need blood" says the embryoid body
Tokyo, Japan -
Embryonic stem cells have a very high potential to generate various tissues, a potential so high that it actually serves as a drawback in some senses. See, embryonic stem cells, when grown in floating cultures form embryoid bodies, and in these embryoid bodies the embryonic stem cell starts differentiating into a wide...
Embryonic Stem Cell Homing
Boston, MA -
Administration of bone marrow derived stem cells to patients post-infarct has demonstrated positive clinical results in double blind trials. Additionally, Osiris Therapeutics has reported intravenous administration of allogeneic mesenchymal stem cellsFriday February 29th, 2008 @ 15:52:20 EST
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A New Age in Regenerative Medicine
Kyoto, Japan -
In a recent paper Takahashi K et al. Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors.Cell. 2007 Nov 20 generation of an "inducible pluripotent stem cell" or iPS from human skin was announced.
Here is a video... Philadelphia, Pennsylvania -
Cellular positioning during embryogenesis is a complex process involving numerous soluble and cell surface bound factors. A recent paper (Rula et al. Cell autonomous sorting and surface positioning in the formation of primitive endoderm in embryoid bodies. Genesis. 2007 May 15;45(6):327-338) using artificially generated embryoid bodies to further investigate... Beijing, China -
The generation of oocyte-like cells from embryonic stem cells is described in the current paper (Qing et al. Induction of oocyte-like cells from mouse embryonic stem cells by co-culture with ovarian granulosa cells. Differentiation. 2007 May 9).
Following the previous example of neural coculture stimulating
Embryoid Bodies as Models of Embryogenesis
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Oocytes from ES cells
OCT-4 Challenged
Milan, Italy - The ability of molecular and cellular biologists to distinguish cells of various potency in terms of "stemness" is greatly assisted by specific cellular markers. For example, hematopoietic stem cells are known to contain the marker CD34, which acts as an adhesion molecule, but also is somewhat specific to cells capable of producing other blood cells...
Skin as Nuclear Transfer Donor
New York, NY - Various methods of nuclear transfer cloning are known in the art. However, what is interesting is the actual optimal donor cell to be used for the highest efficiency, since in general the process of nuclear transfer cloning is considered to be generally inefficient. In a recent paper (Li et al. Mice cloned from...
Accumulation of Abnormalities
Indianapolis, IN - It is known that embryonic stem cells offer almost limitless possibilities for regenerative medicine. In fact, there are reports in the published literature that human embryonic stem cells have actually been used clinically. One of the important aspects of these cells is their high level of telomerase...
Modulation of Histone Deacetylases For Generating Heart Tissue
London, Canada Researchers at the University of Western Ontario have published a paper in the October 15th, 2006, issue of the Journal of Cell Sciences (Karamboulas C et al, HDAC activity regulates entry of mesoderm cells into the cardiac muscle lineage. J Cell Sci. 2006 Oct 15;119(Pt 20):4305-14) describing mechanisms by which inhibition of histone...