Mesenchymal Stem Cells Use HLA-G to Suppress T Cells

Cedex, France - The fact that mesenchymal stem cells are immune suppressive is established. This is one of the reasons why companies such as Osiris are trying to get them approved as an "off the shelf" product that does not require matching. Several mechanisms are known by which mesenchymal stem cells suppress the immune...

MS Patient After Stem Cell Therapy

[Watch the Video] Numerous animal studies support the immunomodulatory activities of stem cells, especially mesenchymal stem cells. For example, expression of molecules such as IDO, IL-10 and TGF-beta by mesenchymal stem cells allows induction of tolerance, generation of Treg cells, as well as veto-like activity. Although there are...

Friday August 3rd, 2007 @ 13:07:47 EST 2 Comments

Insulin transfected mesenchymals for diabetes

Nantong, China - While numerous groups are trying to treat diabetes by inducing differentiation of stem cells into insulin producing cells, other groups are simply transfecting the gene for insulin (or proinsulin) into stem cells and administering the cells. While transfection ensures that the gene will be expressed, it does not...

DNA Immunization for Cancer

[Watch the Video] This video describes a publication that uses "naked" DNA to immunize patients with prostate cancer so as to induce immunity to the antigen PSA. While, T cell mediated immunity was induced, this was primarily in patients treated with higher vaccine doses. The relevance of this to the stem cell community is that as we start identifying...

Stem Cell Therapy for Cerebral Palsy

[Watch the Video] This video describes the scientific rationale for utilization of stem cells to treat cerebral palsy. Few people know that cerebral palsy was treated by Dr. Kurtzburg from Duke using cord blood stem cells. This is described in the video.

Saturday July 28th, 2007 @ 15:06:24 EST 14 Comments

G-CSF for Spinal Cord Injury

Newark, NJ - Numerous stem cell therapeutic approaches are currently under investigation for spinal cord injury. Although it has been demonstrated in animal models that stem cells possess various repairative properties, an important and often overlooked property of stem cells is their ability to produce numerous trophic factors capable of stimulating endogenous healing processes. In a...

Stem Cell Treatment for Autism

Stem Cell Clinic Publishes First Peer Reviewed Paper on Autism Stem Cell Therapy SAN DIEGO--(BUSINESS WIRE)--The Institute for Cellular Medicine (www.cellmedicine.com) announced today what appears to be the first publication in a peer reviewed journal outlining scientific rationale for the use of stem cells in the treatment of...

Sunday July 15th, 2007 @ 16:05:59 EST 3 Comments

Stem Cell Therapy for Autism

[Watch the Video] This video is of a patient who recieved stem cell therapy for autism. The use of stem cell therapy for autism has recently been proposed in the publication Ichim et al. Stem cell therapy for autism. J Transl Med. 2007 Jun 27;5:30

Friday July 13th, 2007 @ 20:16:58 EST 1 Comment

Mesenchymal Stem Cells Do Not Activate Cytotoxic T Lymphocytes

Stockholm, Sweden - Mesenchymal stem cells are far advanced in clinical development with trials being conducted for conditions ranging from multiple sclerosis to Crohn's Disease. One attractive aspects of these cells is their relatively low immunogenicity, thus offering the possibility of performing transfer across allogeneic...