StemCellPatents.com Newsletter

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Last week an interesting news story about >20 Texan patients treated with stem cells suffering from multiple sclerosis came out.  We watch these developments with cautious optimism. Click here for the video.

A recent paper describing TNF-alpha inhibiting SDF-1 secretion was published.  This may explain some of the osteoclastic effects seen in patients with chronic inflammation.  Another interesting finding was that EPO can inhibit the mouse model of multiple sclerosis through stimulation of Treg and inhibition of Th17.  Maybe this is why some cancer patients do worse if they are on chronic EPO?

Two neat patents came out last week.  #7,494,644 covers the transfection of cells (myoblasts and mesenchymal) with connexin-43 to increase their ability to interact with myocardium.  This could be a great way of overcoming arrythmias seen with some myoblast-based approaches.  Irv Weissman continues his patent domination of the field of hematology, getting a patent on the megakaryocytic progenitor (#7,494,807).  He is inventor on the common myeloid progenitor, as well as common lymphoid progenitor patents.  Great job Irv !

Although the majority of studies looking at stem cell mediated immune modulation have been focused on mesenchymal stem cells, a recent paper describes suppression of the mouse model of MS through administration of hematopoietic stem cells, and demonstrated that therapeutic effect was associated with upregulation of indolamine 2,3 deoxygenase in the dendritic cells. 

Methods and compositions for correction of cardiac conduction disturbances     Patent Number: 7,494,644 Assignee | Inventor It is known that bone marrow stem cells are mobilized after heart injury such as infarct, with presumable therapeutic effects mediated by the stem cells in terms of stimulating angiogenesis or even integrating into the damaged myocardium and transdifferentiating into de novo [Read More] Ask a question OR leave your comments.

Stem Cell Therapy for Multiple Sclerosis Monday March 2nd, 2009 @ 20:41:36 EST [Watch the Video] The use of stem cells for treatment of multiple sclerosis has the potential to address both the inflammatory aspects of the disease, as well as induce regeneration.  Above is a clip from a news release describing what appears to be a repeatedly...[Read More] Ask a question OR leave your comments. Read more StemCellPatents.com News

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RECENTLY ADDED PATENTS     Mammary stem cell marker (7,563,619) Assignee | Inventor | Ask a question OR leave your comments     Soft tissue repair and regeneration using postpartum-derived cells (7,560,276) Assignee | Inventor | Ask a question OR leave your comments     Compositions and methods for generating skin (7,560,275) Assignee | Inventor | Ask a question OR leave your comments     Method for reducing neuronal degeneration so as to ameliorate the effects of injury or disease (7,560,102) Assignee | Inventor | Ask a question OR leave your comments     Human cord blood derived unrestricted somatic stem cells (USSC) (7,560,280) Assignee | Inventor | Ask a question OR leave your comments     Human cord blood derived unrestricted somatic stem cells (USSC) (7,556,801) Assignee | Inventor | Ask a question OR leave your comments     Dedifferentiated, programmable stem cells of monocytic origin, and their production and use (7,553,663) Assignee | Inventor | Ask a question OR leave your comments     Stromal antigen-presenting cells and use thereof (7,553,661) Assignee | Inventor | Ask a question OR leave your comments     Directed in vitro differentiation of marrow stromal cells into neural cell progenitors (7,547,545) Assignee | Inventor | Ask a question OR leave your comments     Progenitor cells from wharton's jelly of human umbilical cord (7,547,546) Assignee | Inventor | Ask a question OR leave your comments     View all 1436 Stem Cell Patents on StemCellPatents.com

LATEST NEWS     Leptin Blocks T Regulatory Cell Expansion August 23rd, 2009     Mechanism of Multiple Sclerosis Stem Cell Therapy July 24th, 2009 : 2 Comments     Lithium for Treatment of Multiple Sclerosis July 15th, 2009     Treatment of Degenerative Disc Disease by Bone Marrow Stem Cells July 9th, 2009 : 2 Comments     Apoptotic Cells Secrete Angiogenic Factors June 27th, 2009     Read more news on StemCellPatents.com

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